Plot:
Reggie the turkey has always been afraid of Thanksgiving because turkeys have always been on the menu, but his attempts to warn his farm-based flock constantly fall on deaf ears and has made him an outcast. When the other turkeys finally realize what is going on, they throw Reggie outside in an attempt to save themselves. In a surprise twist of fate, he winds up being named the "pardoned turkey" by the President of the United States and is subsequently taken to Camp David. Although initially hesitant, Reggie soon eases into a routine of doing nothing but enjoying pizza delivered to him by the "Pizza Dude" and watching Mexican telenovelas.
About three days before Thanksgiving, Reggie gets bag-kidnapped by Jake, a member of the Turkey Freedom Front who tells him that a "Great Turkey" told him to find Reggie and take him back to the first Thanksgiving with him to take turkeys off the menu once and for all. They then infiltrate the base where a time machine is located. Despite interference by federal officials and an attempt by Reggie to trick him back to the surface, Jake manages to commandeer an egg-shaped time machine with an A.I. software named S.T.E.V.E. and they time-travel back to the same day in 1621, three days before the first Thanksgiving. Once there, they are immediately attacked and separated by colonial hunters led by Myles Standish. Reggie and Jake are quickly rescued by native turkeys led by Chief Broadbeak and his two children, Ranger and Jenny, the latter of whom Reggie immediately falls for.
Broadbeak explains that the turkeys in the area have been forced underground since the settlers came and that they cannot risk fighting back without the settlers taking them. The next day, Broadbeak orders Jake with Ranger to spy on the settlers and Reggie with Jenny to spring all the hunting traps the humans set up. Despite initial hostility, Ranger and Jake find out that the settlers have already begun preparations for Thanksgiving and where they keep their weapons. Meanwhile, Jenny believes in Reggie for lying about being from the future and is impressed with his accidental unorthodox way of springing the traps. However, they are soon intercepted by Standish and Reggie is forced to get her in orbit over the planet aboard S.T.E.V.E., validating everything he said in the process. Reggie asks Jenny to go back to the future with him once everything blows over, but she refuses to leave the flock no matter how much she likes him. Jake then drags Reggie away and tells him he has a plan to attack the settlers. However, Reggie has gotten sick of all his unapproved stories and threatens to leave.Desperate, Jake tells him that this trip was more about him making up for his failure to save turkey eggs while escaping a turkey-fattening facility when he was young, maintaining that the Great Turkey convinced him to go through with this. While still reluctant to believe what he said, Reggie still goes along with the plan. They manage to use gunpowder to destroy the weapons shack, but Jake inadvertently leaves a gunpowder trail back to the tree the turkeys are hiding under. Standish and his men flush the turkeys out from underground, capturing enough for the feast and killing Broadbeak in the ensuing panic. Jenny is sworn in as the new chief and orders the remaining turkeys to prepare an attack on the settlers.
Despite Jake's attempts to get him to stay, a heartbroken Reggie heads back to the present day at Camp David, where he is confronted by three future versions of himself. Through the awkward conversation, Reggie discovers from one of them that he is the Great Turkey, having used S.T.E.V.E. to throw his voice and appearance. Inspired, Reggie goes back in time to stop the attack, inadvertently trapping Standish in the time stream and erasing him from history in the process. Through S.T.E.V.E. and the Pizza Dude, Reggie convinces the settlers and the arriving Indians that pizza is a more acceptable food than turkeys, taking them off the Thanksgiving menu entirely. In the end, Reggie decides to stay with Jenny while Jake takes S.T.E.V.E. in order to look for new adventures. However, Jake returns moments after leaving and implies to Reggie and Jenny that he needs help putting an end to the turducken.